Queen Elizabeth National Park occupies an estimated 1,978 square kilometres (764 sq mi), it lies in the districts of Kasese District, District. The area of the park extends from Lake George in the northeast to Lake Edward in the southwest, and includes the Kazinga Channel that connects the two lakes. The park is named after Queen Elizabeth II and was established in 1954. The park was later renamed Ruwenzori before it returned to its royal name. QENP is known for its wildlife, although many animals were killed in the Uganda-Tanzania War. Many species have recovered, including hippopotamuses, elephants, leopards, lions and chimpanzees; it is now home to 95 species of mammal and over 500 species of birds.

The area around Ishasha in Rukungiri District is famous for its tree-climbing lions, whose males sport black manes, a feature unique to the lions in this area. The park is also famous for its volcanic features, comprising volcanic cones and deep craters, many with crater lakes such as Lake Katwe, from which salt is extracted. The national park includes the Maramagambo Forest and borders Kigezi Game Reserve, Kyambura Game Reserve and Kibale National Park in Uganda, and the Virunga National Park in the Democratic Republic of Congo. Main activities include chimpanzee tracking, game drive around the park, boat cruise, and bird watching and many more.